PET Imaging of Acidic Tumor Environment With 89Zr-labeled pHLIP Probes

PET Imaging of Acidic Tumor Environment With 89Zr-labeled pHLIP Probes

Acidosis of the tumor microenvironment is a hallmark of tumor progression and has emerged as an essential biomarker for cancer diagnosis, prognosis, and evaluation of treatment response. A tool for quantitatively visualizing the acidic tumor environment could significantly advance our understanding...

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Bibliographic Details
Main Authors: David Bauer, Hannah Visca, Anuradha Weerakkody, Lukas M. Carter, Zachary Samuels, Spencer Kaminsky, Oleg A. Andreev, Yana K. Reshetnyak, Jason S. Lewis
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
pH-low insertion peptides
membrane-insertion behavior
acidic tumor microenvironment
zirconium-89
PET imaging
human dosimetry estimates
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.882541/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.882541/full

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