Absolute Configuration Determination of Retroflexanone Using the Advanced Mosher Method and Application of HPLC-NMR

The absolute configuration of retroflexanone (1) and a closely related phlorogluinol (2) was established using the advanced Mosher method and by application of HPLC-NMR. HPLC-NMR permitted a small scale Mosher method analysis to be carried out on these unstable phloroglucinols.

Bibliographic Details
Main Authors: Caleb Singleton, Robert Brkljača, Sylvia Urban
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Marine Drugs
Subjects:
Online Access:http://www.mdpi.com/1660-3397/16/6/205