Characterization of a novel HLA-A*11:335 allele resulting from a rare interlocus recombination involving HLA-A*11:01:01:01/126 and HLA-H*02:07/14/18 alleles with nanopore sequencing, in a volunteer from the China Marrow Donor Program

Characterization of a novel HLA-A*11:335 allele resulting from a rare interlocus recombination involving HLA-A*11:01:01:01/126 and HLA-H*02:07/14/18 alleles with nanopore sequencing, in a volunteer from the China Marrow Donor Program

Abstract Background The major histocompatibility complex (MHC) in humans includes three classical class I loci (A, B, and C), which are important biomarkers for the transplantation of organs and hematopoietic stem cells. In the MHC, polymorphism is known to be extremely high while interlocus recombi...

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Bibliographic Details
Main Authors: Li-Qun Zhang, Erik Rozemuller, Dan Wang, Xiang-Jun Liu, Jian-Ping Cai
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Medical Genomics
Subjects:
HLA-A*11:335
Interlocus recombination
NGS
Nanopore sequencing
Online Access:https://doi.org/10.1186/s12920-022-01176-1

Internet

https://doi.org/10.1186/s12920-022-01176-1

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