Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response

Long noncoding RNA molecules are RNA transcripts long thought to remain untranslated. In this study, the authors demonstrate that certain lncRNA can be translated into peptides that are immunogenic to CD8+ T cells and promote anti-tumour responses when delivered as vaccine vectors in mice.

Bibliographic Details
Main Authors: Wojciech Barczak, Simon M. Carr, Geng Liu, Shonagh Munro, Annalisa Nicastri, Lian Ni Lee, Claire Hutchings, Nicola Ternette, Paul Klenerman, Alexander Kanapin, Anastasia Samsonova, Nicholas B. La Thangue
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36826-0

Internet

https://doi.org/10.1038/s41467-023-36826-0

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