Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response
Long noncoding RNA molecules are RNA transcripts long thought to remain untranslated. In this study, the authors demonstrate that certain lncRNA can be translated into peptides that are immunogenic to CD8+ T cells and promote anti-tumour responses when delivered as vaccine vectors in mice.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36826-0 |
| _version_ | 1797864200725331968 |
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| author | Wojciech Barczak Simon M. Carr Geng Liu Shonagh Munro Annalisa Nicastri Lian Ni Lee Claire Hutchings Nicola Ternette Paul Klenerman Alexander Kanapin Anastasia Samsonova Nicholas B. La Thangue |
| author_facet | Wojciech Barczak Simon M. Carr Geng Liu Shonagh Munro Annalisa Nicastri Lian Ni Lee Claire Hutchings Nicola Ternette Paul Klenerman Alexander Kanapin Anastasia Samsonova Nicholas B. La Thangue |
| author_sort | Wojciech Barczak |
| collection | DOAJ |
| description | Long noncoding RNA molecules are RNA transcripts long thought to remain untranslated. In this study, the authors demonstrate that certain lncRNA can be translated into peptides that are immunogenic to CD8+ T cells and promote anti-tumour responses when delivered as vaccine vectors in mice. |
| first_indexed | 2024-04-09T22:49:05Z |
| format | Article |
| id | doaj.art-23d754b5fcb74be2b6886c3854660ad7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:05Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-23d754b5fcb74be2b6886c3854660ad72023-03-22T11:42:16ZengNature PortfolioNature Communications2041-17232023-02-0114111710.1038/s41467-023-36826-0Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour responseWojciech Barczak0Simon M. Carr1Geng Liu2Shonagh Munro3Annalisa Nicastri4Lian Ni Lee5Claire Hutchings6Nicola Ternette7Paul Klenerman8Alexander Kanapin9Anastasia Samsonova10Nicholas B. La Thangue11Laboratory of Cancer Biology, Department of Oncology, University of OxfordLaboratory of Cancer Biology, Department of Oncology, University of OxfordLaboratory of Cancer Biology, Department of Oncology, University of OxfordArgonaut Therapeutics Ltd, Oxford Science ParkThe Jenner Institute, Nuffield Department of Medicine, University of OxfordPeter Medawar Building for Pathogen Research, University of OxfordPeter Medawar Building for Pathogen Research, University of OxfordThe Jenner Institute, Nuffield Department of Medicine, University of OxfordPeter Medawar Building for Pathogen Research, University of OxfordCentre for Computational Biology, Peter the Great Saint Petersburg Polytechnic UniversityCentre for Computational Biology, Peter the Great Saint Petersburg Polytechnic UniversityLaboratory of Cancer Biology, Department of Oncology, University of OxfordLong noncoding RNA molecules are RNA transcripts long thought to remain untranslated. In this study, the authors demonstrate that certain lncRNA can be translated into peptides that are immunogenic to CD8+ T cells and promote anti-tumour responses when delivered as vaccine vectors in mice.https://doi.org/10.1038/s41467-023-36826-0 |
| spellingShingle | Wojciech Barczak Simon M. Carr Geng Liu Shonagh Munro Annalisa Nicastri Lian Ni Lee Claire Hutchings Nicola Ternette Paul Klenerman Alexander Kanapin Anastasia Samsonova Nicholas B. La Thangue Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response Nature Communications |
| title | Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response |
| title_full | Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response |
| title_fullStr | Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response |
| title_full_unstemmed | Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response |
| title_short | Long non-coding RNA-derived peptides are immunogenic and drive a potent anti-tumour response |
| title_sort | long non coding rna derived peptides are immunogenic and drive a potent anti tumour response |
| url | https://doi.org/10.1038/s41467-023-36826-0 |
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