B cell autoimmunity and bone damage in rheumatoid arthritis

Rheumatoid arthritis (RA) is a chronic immune-inflammatory disease associated with significant bone damage. Pathological bone remodeling in RA is primarily driven by persistent inflammation. Indeed, pro-inflammatory cytokines stimulate the differentiation of bone-resorbing osteoclasts and, in parall...

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Bibliographic Details
Main Authors: S. Bugatti, L. Bogliolo, C. Montecucco, A. Manzo
Format: Article
Language:English
Published: PAGEPress Publications 2016-12-01
Series:Reumatismo
Subjects:
Online Access:http://www.reumatismo.org/index.php/reuma/article/view/914