B cell autoimmunity and bone damage in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic immune-inflammatory disease associated with significant bone damage. Pathological bone remodeling in RA is primarily driven by persistent inflammation. Indeed, pro-inflammatory cytokines stimulate the differentiation of bone-resorbing osteoclasts and, in parall...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-12-01
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| Series: | Reumatismo |
| Subjects: | |
| Online Access: | http://www.reumatismo.org/index.php/reuma/article/view/914 |
| _version_ | 1811302545195270144 |
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| author | S. Bugatti L. Bogliolo C. Montecucco A. Manzo |
| author_facet | S. Bugatti L. Bogliolo C. Montecucco A. Manzo |
| author_sort | S. Bugatti |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is a chronic immune-inflammatory disease associated with significant bone damage. Pathological bone remodeling in RA is primarily driven by persistent inflammation. Indeed, pro-inflammatory cytokines stimulate the differentiation of bone-resorbing osteoclasts and, in parallel, suppress osteoblast function, resulting in net loss of bone. Abating disease activity thus remains the major goal of any treatment strategy in patients with RA. Autoantibody-positive patients, however, often show a rapidly progressive destructive course of the disease, disproportionate to the level of inflammation. The epidemiological association between RA-specific autoantibodies, in particular anti-citrullinated protein autoantibodies, and poor structural outcomes has recently found mechanistic explanation in the multiple roles that B cells play in bone remodeling. In this review, we will summarize the substantial progress that has been made in deciphering how B cells and autoantibodies negatively impact on bone in the course of RA, through both inflammation-dependent and independent mechanisms. |
| first_indexed | 2024-04-13T07:30:58Z |
| format | Article |
| id | doaj.art-23d7b0bb1f074b998c00c758f5fd0c84 |
| institution | Directory Open Access Journal |
| issn | 0048-7449 2240-2683 |
| language | English |
| last_indexed | 2024-04-13T07:30:58Z |
| publishDate | 2016-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj.art-23d7b0bb1f074b998c00c758f5fd0c842022-12-22T02:56:21ZengPAGEPress PublicationsReumatismo0048-74492240-26832016-12-0168311712510.4081/reumatismo.2016.914717B cell autoimmunity and bone damage in rheumatoid arthritisS. Bugatti0L. Bogliolo1C. Montecucco2A. Manzo3Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of PaviaRheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of PaviaRheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of PaviaRheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of PaviaRheumatoid arthritis (RA) is a chronic immune-inflammatory disease associated with significant bone damage. Pathological bone remodeling in RA is primarily driven by persistent inflammation. Indeed, pro-inflammatory cytokines stimulate the differentiation of bone-resorbing osteoclasts and, in parallel, suppress osteoblast function, resulting in net loss of bone. Abating disease activity thus remains the major goal of any treatment strategy in patients with RA. Autoantibody-positive patients, however, often show a rapidly progressive destructive course of the disease, disproportionate to the level of inflammation. The epidemiological association between RA-specific autoantibodies, in particular anti-citrullinated protein autoantibodies, and poor structural outcomes has recently found mechanistic explanation in the multiple roles that B cells play in bone remodeling. In this review, we will summarize the substantial progress that has been made in deciphering how B cells and autoantibodies negatively impact on bone in the course of RA, through both inflammation-dependent and independent mechanisms.http://www.reumatismo.org/index.php/reuma/article/view/914Rheumatoid arthritisboneB-lymphocytesanti-citrullinated protein autoantibodiesrheumatoid factor. |
| spellingShingle | S. Bugatti L. Bogliolo C. Montecucco A. Manzo B cell autoimmunity and bone damage in rheumatoid arthritis Reumatismo Rheumatoid arthritis bone B-lymphocytes anti-citrullinated protein autoantibodies rheumatoid factor. |
| title | B cell autoimmunity and bone damage in rheumatoid arthritis |
| title_full | B cell autoimmunity and bone damage in rheumatoid arthritis |
| title_fullStr | B cell autoimmunity and bone damage in rheumatoid arthritis |
| title_full_unstemmed | B cell autoimmunity and bone damage in rheumatoid arthritis |
| title_short | B cell autoimmunity and bone damage in rheumatoid arthritis |
| title_sort | b cell autoimmunity and bone damage in rheumatoid arthritis |
| topic | Rheumatoid arthritis bone B-lymphocytes anti-citrullinated protein autoantibodies rheumatoid factor. |
| url | http://www.reumatismo.org/index.php/reuma/article/view/914 |
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