Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes
In the present study a series of 34 synthetic ligustrazine-containing α, β-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was se...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2021-10-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100524&tlng=en |
| _version_ | 1828924460036521984 |
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| author | Abdulsalam A. M. Alkhaldi Harry P. de Koning Syed Nasir Abbas Bukhari |
| author_facet | Abdulsalam A. M. Alkhaldi Harry P. de Koning Syed Nasir Abbas Bukhari |
| author_sort | Abdulsalam A. M. Alkhaldi |
| collection | DOAJ |
| description | In the present study a series of 34 synthetic ligustrazine-containing α, β-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selected as the core moiety for the synthesis of α, β-Unsaturated carbonyl-based compounds and these compounds were selected as precursors for the synthesis of new oximes. Some derivates, including 5f and 6i, showed multiple activities against all tested strains. In particular compounds 5f and 8o are the most potent and they are, therefore, potential candidates for trypanosomiasis and leishmaniasis |
| first_indexed | 2024-12-13T22:56:35Z |
| format | Article |
| id | doaj.art-23d9b47c8cfb4830b7306357825ccc13 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-13T22:56:35Z |
| publishDate | 2021-10-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-23d9b47c8cfb4830b7306357825ccc132022-12-21T23:28:29ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902021-10-015710.1590/s2175-97902020000418997Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentesAbdulsalam A. M. AlkhaldiHarry P. de KoningSyed Nasir Abbas Bukharihttps://orcid.org/0000-0001-8125-7972In the present study a series of 34 synthetic ligustrazine-containing α, β-Unsaturated carbonyl-based compounds and oximes, recognized as anticancer compounds were assessed against protozoa of the Trypanosoma and Leishmania species. Ligustrazine, chemically known as tetramethylpyrazine (TMP), was selected as the core moiety for the synthesis of α, β-Unsaturated carbonyl-based compounds and these compounds were selected as precursors for the synthesis of new oximes. Some derivates, including 5f and 6i, showed multiple activities against all tested strains. In particular compounds 5f and 8o are the most potent and they are, therefore, potential candidates for trypanosomiasis and leishmaniasishttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100524&tlng=enProtozoan parasites. Sleeping sickness. α,β-Unsaturated carbonyl-based compoundstoxicity. Organic synthesis |
| spellingShingle | Abdulsalam A. M. Alkhaldi Harry P. de Koning Syed Nasir Abbas Bukhari Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes Brazilian Journal of Pharmaceutical Sciences Protozoan parasites. Sleeping sickness. α,β-Unsaturated carbonyl-based compounds toxicity. Organic synthesis |
| title | Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes |
| title_full | Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes |
| title_fullStr | Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes |
| title_full_unstemmed | Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes |
| title_short | Synthetic ligustrazine based cyclohexanone and oxime analogs as Anti-Trypanosoma and Anti-Leishmanial agentes |
| title_sort | synthetic ligustrazine based cyclohexanone and oxime analogs as anti trypanosoma and anti leishmanial agentes |
| topic | Protozoan parasites. Sleeping sickness. α,β-Unsaturated carbonyl-based compounds toxicity. Organic synthesis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100524&tlng=en |
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