Development of covalent inhibitors: Principle, design, and application in cancer

Development of covalent inhibitors: Principle, design, and application in cancer

Abstract Covalent inhibitors have been a rapidly growing field in drug discovery due to their therapeutic potential and unique advantages in cancer therapy. As opposed to noncovalent inhibitory drugs, covalent inhibitors reversibly or irreversibly modify proximal nucleophilic amino acid residues on...

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Bibliographic Details
Main Authors: Lang Zheng, Yang Li, Defa Wu, Huan Xiao, Shilong Zheng, Guan Wang, Qiu Sun
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:MedComm – Oncology
Subjects:
cancer therapy
covalent inhibitors
drug discovery
noncysteine residues
Online Access:https://doi.org/10.1002/mog2.56

Internet

https://doi.org/10.1002/mog2.56

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