Waste not, want not: why rarefying microbiome data is inadmissible.
Current practice in the normalization of microbiome count data is inefficient in the statistical sense. For apparently historical reasons, the common approach is either to use simple proportions (which does not address heteroscedasticity) or to use rarefying of counts, even though both of these appr...
| Asıl Yazarlar: | , |
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| Materyal Türü: | Makale |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Public Library of Science (PLoS)
2014-04-01
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| Seri Bilgileri: | PLoS Computational Biology |
| Online Erişim: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003531&type=printable |