Definitions matter: Heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta-analysis.

Definitions matter: Heterogeneity of COVID-19 disease severity criteria and incomplete reporting compromise meta-analysis.

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Therapeutic efficacy in COVID-19 is dependent upon disease severity (treatment effect heterogeneity). Unfortunately, definitions of severity vary widely. This compromises the meta-analysis of randomised controlled trials (RCTs) and the therapeutic guidelines derived from them. The World Health Organ...

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Bibliographic Details
Main Authors: Philippe J Guérin, Alistair R D McLean, Sumayyah Rashan, AbdulAzeez Lawal, James A Watson, Nathalie Strub-Wourgaft, Nicholas J White
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLOS Global Public Health
Online Access:https://doi.org/10.1371/journal.pgph.0000561

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https://doi.org/10.1371/journal.pgph.0000561

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