The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells

The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells

Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra. The pathological hallmark of PD is the appearance of intraneuronal cytoplasmic α-synuclein (α-Syn) aggregation, called Lewy bodies. α-Syn aggregation is deeply...

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Bibliographic Details
Main Authors: Ayaka Fujimaki, Kazuki Ohuchi, Shinnosuke Takizawa, Takanori Murakami, Hisaka Kurita, Isao Hozumi, Xiaopeng Wen, Yoshihisa Kitamura, Zhiliang Wu, Yoichi Maekawa, Masatoshi Inden
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42903-7

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https://doi.org/10.1038/s41598-023-42903-7

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