Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function

Cigarette smoke exposure reduces hemorrhagic shock induced circulatory dysfunction in mice with attenuated glucocorticoid receptor function

IntroductionWe previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, which leads to tissue hypoxia and inflammation with ri...

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Bibliographic Details
Main Authors: Martin Wepler, Jonathan M. Preuss, Cornelia Tilp, Martina Keck, Jochen Blender, Ulrich Wachter, Tamara Merz, Josef Vogt, Sandra Kress, Michael Gröger, Andrea Hoffmann, Marina Fink, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
catecholamines
cigarettes smoke exposure
glucocorticoid receptor function
hemodynamic function
hemorrhagic shock
metabolic function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.980707/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.980707/full

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