Design, Synthesis and 5-HT<sub>1A</sub> Binding Affinity of <i>N</i>-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)tricyclo[3.3.1.1<sup>3,7</sup>]decan-1-amine and <i>N</i>-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)-3,5-dimethyl-tricylo[3.3.1.1<sup>3,7</sup>]decan-1-amine

Design, Synthesis and 5-HT<sub>1A</sub> Binding Affinity of <i>N</i>-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)tricyclo[3.3.1.1<sup>3,7</sup>]decan-1-amine and <i>N</i>-(3-(4-(2-Methoxyphenyl)piperazin-1-yl)propyl)-3,5-dimethyl-tricylo[3.3.1.1<sup>3,7</sup>]decan-1-amine

Based on previously highlighted structural features, the development of highly selective 5-HT<sub>1A</sub> receptor inhibitors is closely linked to the incorporation of a 4-alkyl-1-arylpiperazine scaffold on them. In this paper, we present the synthesis of two new compounds bearing the 2...

Full description

Bibliographic Details
Main Authors: Grigoris Zoidis, María Isabel Loza, Marco Catto
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molbank
Subjects:
serotonin receptors
5-HT<sub>1A</sub> receptors
arylpiperazine inhibitors
carbocyclic rings
cage-like structures
blood-brain barrier
Online Access:https://www.mdpi.com/1422-8599/2022/1/M1353

Internet

https://www.mdpi.com/1422-8599/2022/1/M1353

Similar Items