Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

Sonic Hedgehog Signaling Pathway Mediates Proliferation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via MAPK/ERK Signaling Pathway

Fibroblast-like synoviocytes (FLSs) are the major effector cells that lead to rheumatoid arthritis (RA) synovitis and joint destruction. Our previous studies showed that Sonic Hedgehog (SHH) signaling pathway is involved in aberrant activation of RA-FLSs and inhibition of SHH pathway decreases proli...

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Bibliographic Details
Main Authors: Fang Liu, Xiao Xue Feng, Shang Ling Zhu, Hong Yu Huang, Ying Di Chen, Yun Feng Pan, Rayford R. June, Song Guo Zheng, Jian Lin Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
arthritis
rheumatoid
Sonic Hedgehog
mitogen-activated protein kinases
cell proliferation
cell migration
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02847/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02847/full

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