Implication of Lactucopicrin in Autophagy, Cell Cycle Arrest and Oxidative Stress to Inhibit U87Mg Glioblastoma Cell Growth

Implication of Lactucopicrin in Autophagy, Cell Cycle Arrest and Oxidative Stress to Inhibit U87Mg Glioblastoma Cell Growth

In this study, we propose lactucopicrin (LCTP), a natural sesquiterpene lactone from Lactucavirosa, as a molecule able to control the growth of glioblastoma continuous cell line U87Mg. The IC50 of U87Mg against LCTP revealed a strong cytotoxic effect. Daily administration of LCTP showed a dose and t...

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Bibliographic Details
Main Authors: Rossella Rotondo, Maria Antonietta Oliva, Sabrina Staffieri, Salvatore Castaldo, Felice Giangaspero, Antonietta Arcella
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Molecules
Subjects:
glioblastoma (GBM)
lactucopicrin (LCTP)
temozolomide (TMZ)
autophagy
oxidative stress
NF-κB
Online Access:https://www.mdpi.com/1420-3049/25/24/5843

Internet

https://www.mdpi.com/1420-3049/25/24/5843

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