Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture

Divergent effects of itaconate isomers on Coxiella burnetii growth in macrophages and in axenic culture

Aconitate decarboxylase-1 (ACOD1) is expressed by activated macrophages and generates itaconate that exerts anti-microbial and immunoregulatory effects. ACOD1-itaconate is essential for macrophage-mediated control of the intracellular pathogen Coxiella (C.) burnetii, which causes Q fever. Two isomer...

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Bibliographic Details
Main Authors: Md Nur A Alam Siddique, Fabian Kellermeier, Martha Ölke, Mingming Zhao, Konrad Büssow, Peter J. Oefner, Anja Lührmann, Katja Dettmer, Roland Lang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Immunology
Subjects:
ACOD1
IRG1
itaconate
mesaconate
citraconate
uptake
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427457/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1427457/full

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