An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD

An in silico model of retinal cholesterol dynamics (RCD model): insights into the pathophysiology of dry AMD

We developed an in silico mathematical model of retinal cholesterol (Ch) dynamics (RCD) to quantify the physiological rate of Ch turnover in the rod outer segment (ROS), the lipoprotein transport mechanisms by which Ch enters and leaves the outer retina, and the rates of drusen growth and macrophage...

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Bibliographic Details
Main Authors: Seyedeh Maryam Zekavat, James Lu, Cyrille Maugeais, Norman A. Mazer
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Journal of Lipid Research
Subjects:
cell/tissue
eye/retina
high density lipoprotein/metabolism
low density lipoprotein/metabolism
lipoproteins/kinetics
lipoproteins/metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335847

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http://www.sciencedirect.com/science/article/pii/S0022227520335847

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