Phosphatidylcholine Cation—Tyrosine π Complexes: Motifs for Membrane Binding by a Bacterial Phospholipase C

Phosphatidylcholine Cation—Tyrosine π Complexes: Motifs for Membrane Binding by a Bacterial Phospholipase C

Phosphatidylinositol-specific phospholipase C (PI-PLC) enzymes are a virulence factor in many Gram-positive organisms. The specific activity of the <i>Bacillus thuringiensis</i> PI-PLC is significantly increased by adding phosphatidylcholine (PC) to vesicles composed of the substrate pho...

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Bibliographic Details
Main Authors: Mary F. Roberts, Anne Gershenson, Nathalie Reuter
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
phosphatidylinositol
PI-specific phospholipase C
phosphatidylcholine
NMR relaxometry
molecular dynamic simulations
cation-π interaction
Online Access:https://www.mdpi.com/1420-3049/27/19/6184

Internet

https://www.mdpi.com/1420-3049/27/19/6184

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