Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress

Targeting TXNIP in endothelial progenitors mitigates IL-8-induced neutrophil recruitment under metabolic stress

Abstract Background This study explores the potential role of Thioredoxin-interacting protein (TXNIP) silencing in endothelial colony-forming cells (ECFCs) within the scope of age-related comorbidities and impaired vascular repair. We aim to elucidate the effects of TXNIP silencing on vasculogenic p...

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Bibliographic Details
Main Authors: Julia Jolibois, Alison Domingues, Divina El Hamaoui, Raphaël Awaida, Mathilde Berger-de-Gaillardo, Daniel Guérin, David M Smadja, Perrine Marquet-DeRougé, Isabelle Margaill, Elisa Rossi, Valérie Nivet-Antoine
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Stem Cell Research & Therapy
Subjects:
Endothelial progenitors
Metabolic stress
Age-related comorbidities
TXNIP
Cytokine secretion
Neutrophils
Online Access:https://doi.org/10.1186/s13287-024-03850-w

Internet

https://doi.org/10.1186/s13287-024-03850-w

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