The genomic analysis of lactic acidosis and acidosis response in human cancers.

The tumor microenvironment has a significant impact on tumor development. Two important determinants in this environment are hypoxia and lactic acidosis. Although lactic acidosis has long been recognized as an important factor in cancer, relatively little is known about how cells respond to lactic a...

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Bibliographic Details
Main Authors: Julia Ling-Yu Chen, Joseph E Lucas, Thies Schroeder, Seiichi Mori, Jianli Wu, Joseph Nevins, Mark Dewhirst, Mike West, Jen-Tsan Chi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-12-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2585811?pdf=render