Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice

Diverse Response to Local Pharmacological Blockade of Sirt1 Cleavage in Age-Induced versus Trauma-Induced Osteoarthritis Female Mice

<b>Objective</b>: Previous studies have shown that the cleavage of Sirt1 contributes to the development of osteoarthritis (OA). In fact, OA was effectively abrogated by the intra-articular (IA) administration of two compounds, one blocking Sirt1 cleavage (CA074me) and the other activatin...

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Bibliographic Details
Main Authors: Yonathan H. Maatuf, Miya Marco, Shani Unger-Gelman, Eli Farhat, Anna Zobrab, Ankita Roy, Ashish Kumar, Idan Carmon, Eli Reich, Mona Dvir-Ginzberg
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Biomolecules
Subjects:
Sirt1
aging
intra-articular
osteoarthritis
senescence
Online Access:https://www.mdpi.com/2218-273X/14/1/81

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https://www.mdpi.com/2218-273X/14/1/81

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