Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits

Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits

Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of monocytes, which could lead to inflammatory diseases including atherosclerosis and metabolic syndrome. Sodium 4-phenylbutyrate is a potential therapeutic compound which can reduce the inflammation caused by SD-...

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Bibliographic Details
Main Authors: Jiyoung Lee, Shuo Geng, Song Li, Liwu Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
monocyte
machine learning
inflammation
regulatory motifs
single cell analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627036/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.627036/full

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