A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies

A Dry Powder Platform for Nose-to-Brain Delivery of Dexamethasone: Formulation Development and Nasal Deposition Studies

Nasal route of administration offers a unique opportunity of brain targeted drug delivery via olfactory and trigeminal pathway, providing effective CNS concentrations at lower doses and lower risk for adverse reactions compared to systemic drug administration. Therefore, it has been recently propose...

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Bibliographic Details
Main Authors: Laura Nižić Nodilo, Ivo Ugrina, Drago Špoljarić, Daniela Amidžić Klarić, Cvijeta Jakobušić Brala, Mirna Perkušić, Ivan Pepić, Jasmina Lovrić, Vesna Saršon, Maša Safundžić Kučuk, Dijana Zadravec, Livije Kalogjera, Anita Hafner
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
dexamethasone sodium phosphate
nose-to-brain delivery
spray-dried microspheres
pectin
hypromellose
mannitol
Online Access:https://www.mdpi.com/1999-4923/13/6/795

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https://www.mdpi.com/1999-4923/13/6/795

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