Using incomplete trios to boost confidence in family based association studies

Using incomplete trios to boost confidence in family based association studies

Most currently available family based association tests are designed to account only for nuclear families with complete genotypes for parents as well as offspring. Due to the availability of increasingly less expensive generation of whole genome sequencing information, genetic studies are able to co...

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Bibliographic Details
Main Authors: Varsha eDhankani, David L Gibbs, Theo eKnijnenburg, Roger eKramer, Joseph eVockley, John eNiederhuber, Ilya eShmulevich, Brady eBernard
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-03-01
Series:Frontiers in Genetics
Subjects:
confidence intervals
population stratification
whole genome analysis
Family based association tests
missing genotypes
randomized imputation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00034/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2016.00034/full

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