Proteasome localization and activity in pig brain and in vivo small molecule screening for activators
IntroductionLoss of proteasome function, proteinopathy, and proteotoxicity may cause neurodegeneration across the human lifespan in several forms of brain injury and disease. Drugs that activate brain proteasomes in vivo could thus have a broad therapeutic impact in neurology.MethodsUsing pigs, a cl...
| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Frontiers Media S.A.
2024-02-01
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| coleção: | Frontiers in Cellular Neuroscience |
| Assuntos: | |
| Acesso em linha: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1353542/full |