Proteasome localization and activity in pig brain and in vivo small molecule screening for activators

Proteasome localization and activity in pig brain and in vivo small molecule screening for activators

IntroductionLoss of proteasome function, proteinopathy, and proteotoxicity may cause neurodegeneration across the human lifespan in several forms of brain injury and disease. Drugs that activate brain proteasomes in vivo could thus have a broad therapeutic impact in neurology.MethodsUsing pigs, a cl...

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Bibliographic Details
Main Authors: Adriana Amrein Almira, May W. Chen, Nagat El Demerdash, Cameron Javdan, Dongseok Park, Jennifer K. Lee, Lee J. Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
aging
chlorpromazine
encephalopathy
neonatal brain injury
protein aggregation
proteinopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2024.1353542/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2024.1353542/full

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