The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection

The deubiquitinase OTUD4 inhibits the expression of antimicrobial peptides in Paneth cells to support intestinal inflammation and bacterial infection

Dysfunction of the intestinal epithelial barrier causes microbial invasion that would lead to inflammation in the gut. Antimicrobial peptides (AMPs) are essential components of the intestinal epithelial barrier, while the regulatory mechanisms of AMPs expression are not fully characterized. Here, we...

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Bibliographic Details
Main Authors: Keying Yu, Yu-Yao Guo, Tianzi Liuyu, Peng Wang, Zhi-Dong Zhang, Dandan Lin, Bo Zhong
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Cell Insight
Subjects:
OTUD4
Colitis
Bacterial infection
Antimicrobial peptides
MyD88
Deubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S277289272300024X

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http://www.sciencedirect.com/science/article/pii/S277289272300024X

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