Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App NL−G−F knock-in Alzheimer mice

Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App NL−G−F knock-in Alzheimer mice

Abstract Background Alzheimer’s disease (AD) is an age-related disease characterized by altered cognition, neuroinflammation, and neurodegeneration against which there is presently no effective cure. Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in the learning and memory p...

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Bibliographic Details
Main Authors: Simone Tambaro, Sumonto Mitra, Ruchi Gera, Bengt Linderoth, Lars U. Wahlberg, Taher Darreh-Shori, Homira Behbahani, Per Nilsson, Maria Eriksdotter
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Encapsulated cell biodelivery (ECB)
Brain-derived neurotrophic factor (BDNF)
Alzheimer’s disease (AD)
App NL−G−F knock-in mice
Therapy
Drug delivery
Online Access:https://doi.org/10.1186/s13195-023-01282-x

Internet

https://doi.org/10.1186/s13195-023-01282-x

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