Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer

Regulation and clinical potential of telomerase reverse transcriptase (TERT/hTERT) in breast cancer

Abstract Telomerase reverse transcriptase (TERT/hTERT) serves as the pivotal catalytic subunit of telomerase, a crucial enzyme responsible for telomere maintenance and human genome stability. The high activation of hTERT, observed in over 90% of tumors, plays a significant role in tumor initiation a...

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Bibliographic Details
Main Authors: Ruozhu Yang, Yi Han, Xinyu Guan, Yue Hong, Jiahao Meng, Shirong Ding, Qian Long, Wenjun Yi
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cell Communication and Signaling
Subjects:
Telomerase reverse transcriptase
Breast cancer
Promoter mutations
Epigenetic modifications
Transcriptional regulation
Biomarker
Online Access:https://doi.org/10.1186/s12964-023-01244-8

Internet

https://doi.org/10.1186/s12964-023-01244-8

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