Integrative genetic and single cell RNA sequencing analysis provides new clues to the amyotrophic lateral sclerosis neurodegeneration

Integrative genetic and single cell RNA sequencing analysis provides new clues to the amyotrophic lateral sclerosis neurodegeneration

IntroductionThe gradual loss of motor neurons (MNs) in the brain and spinal cord is a hallmark of amyotrophic lateral sclerosis (ALS), but the mechanisms underlying neurodegeneration in ALS are still not fully understood.MethodsBased on 75 ALS-pathogenicity/susceptibility genes and large-scale singl...

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Bibliographic Details
Main Authors: Hankui Liu, Liping Guan, Min Deng, Lars Bolund, Karsten Kristiansen, Jianguo Zhang, Yonglun Luo, Zhanchi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neuroscience
Subjects:
amyotrophic lateral sclerosis (ALS)
motor neurons (MNs)
single-cell transcriptome
genome-wide association studies (GWAS)
neurological disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1116087/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1116087/full

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