Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3–PEX19 Interaction

Novel Trypanocidal Inhibitors that Block Glycosome Biogenesis by Targeting PEX3–PEX19 Interaction

Human pathogenic trypanosomatid parasites harbor a unique form of peroxisomes termed glycosomes that are essential for parasite viability. We and others previously identified and characterized the essential Trypanosoma brucei ortholog TbPEX3, which is the membrane-docking factor for the cytosolic re...

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Bibliographic Details
Main Authors: Mengqiao Li, Stefan Gaussmann, Bettina Tippler, Julia Ott, Grzegorz M Popowicz, Wolfgang Schliebs, Michael Sattler, Ralf Erdmann, Vishal C Kalel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
neglected tropical diseases
trypanosoma
glycosome biogenesis
protein–protein interaction
PPI inhibitors
alphascreen
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.737159/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.737159/full

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