Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection

Improving Encapsulation of Hydrophilic Chloroquine Diphosphate into Biodegradable Nanoparticles: A Promising Approach against Herpes Virus Simplex-1 Infection

Chloroquine diphosphate (CQ) is a hydrophilic drug with low entrapment efficiency in hydrophobic nanoparticles (NP). Herpes simplex virus type 1 (HSV-1) is an enveloped double-stranded DNA virus worldwide known as a common human pathogen. This study aims to develop chloroquine-loaded poly(lactic aci...

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Bibliographic Details
Main Authors: Tábata Loíse Cunha Lima, Renata de Carvalho Feitosa, Emanuell dos Santos-Silva, Alaine Maria dos Santos-Silva, Emerson Michell da Silva Siqueira, Paula Renata Lima Machado, Alianda Maira Cornélio, Eryvaldo Sócrates Tabosa do Egito, Matheus de Freitas Fernandes-Pedrosa, Kleber Juvenal Silva Farias, Arnóbio Antônio da Silva-Júnior
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
nanoparticles
poly(lactic acid)
chloroquine
antiviral activity
herpes simplex
biological barriers
Online Access:https://www.mdpi.com/1999-4923/10/4/255

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https://www.mdpi.com/1999-4923/10/4/255

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