Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Abstract Background Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by vasculopathy and progressive fibrosis of skin and several internal organs, including lungs. Macrophages are the main cells involved in the immune-inflammatory damage of skin and lungs, and altern...

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Bibliographic Details
Main Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Arthritis Research & Therapy
Subjects:
Alternatively activated macrophages
Fibrosis
Tyrosine kinases inhibitor
Interstitial lung disease
Systemic sclerosis
Online Access:https://doi.org/10.1186/s13075-024-03308-7

Internet

https://doi.org/10.1186/s13075-024-03308-7

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