Recognition of fold- and function-specific sites in the ligand-binding domain of the thyroid hormone receptor-like family

Recognition of fold- and function-specific sites in the ligand-binding domain of the thyroid hormone receptor-like family

BackgroundThe thyroid hormone receptor-like (THR-like) family is the largest transcription factors family belonging to the nuclear receptor superfamily, which directly binds to DNA and regulates the gene expression and thereby controls various metabolic processes in a ligand-dependent manner. The TH...

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Bibliographic Details
Main Authors: Sonia Verma, Soumyananda Chakraborti, Om P. Singh, Veena Pande, Rajnikant Dixit, Amit V. Pandey, Kailash C. Pandey
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Endocrinology
Subjects:
nuclear receptor
thyroid hormone receptor-like family
ligand-binding domain
sequence conservation
phylogeny
relative entropy
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.981090/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.981090/full

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