Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver

Peroxisome proliferator-activated receptor α (PPARα) and PPARγ coactivator 1α (PGC-1α) are crucial transcriptional regulators for genes involved in FA oxidation. Lipin-1 is essential for this increased capacity for β-oxidation in fasted livers, and it is also a phosphatidate phosphatase involved in...

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Bibliographic Details
Main Authors: Bernard P.C. Kok, Jason R.B. Dyck, Thurl E. Harris, David N. Brindley
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520357229