Sendai F/HN pseudotyped lentiviral vector transduces human ciliated and non-ciliated airway cells using α 2,3 sialylated receptors

Sendai F/HN pseudotyped lentiviral vector transduces human ciliated and non-ciliated airway cells using α 2,3 sialylated receptors

A lentiviral vector (LV) pseudotype derived from the fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins of a murine respirovirus (Sendai virus) facilitates efficient targeting of murine lung in vivo. Since targeting of the human lung will depend upon the availability and distribution of r...

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Bibliographic Details
Main Authors: Rosie J. Munday, Tiziana Coradin, Rachael Nimmo, Yatish Lad, Stephen C. Hyde, Kyriacos Mitrophanos, Deborah R. Gill
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lentiviral vector
pseudotype
human airway
Sendai virus
avian influenza virus
sialic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122000948

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http://www.sciencedirect.com/science/article/pii/S2329050122000948

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