Inhibition of lysyl oxidase‐like 2 overcomes adhesion‐dependent drug resistance in the collagen‐enriched liver cancer microenvironment

Inhibition of lysyl oxidase‐like 2 overcomes adhesion‐dependent drug resistance in the collagen‐enriched liver cancer microenvironment

Abstract The tumor microenvironment (TME) is considered to be one of the vital mediators of tumor progression. Extracellular matrix (ECM), infiltrating immune cells, and stromal cells collectively constitute the complex ecosystem with varied biochemical and biophysical properties. The development of...

Full description

Bibliographic Details
Main Authors:	Lanqi Gong, Yu Zhang, Yuma Yang, Qian Yan, Jifeng Ren, Jie Luo, Yuen Chak Tiu, Xiaona Fang, Beilei Liu, Raymond Hiu Wai Lam, Ka‐On Lam, Anne Wing‐Mui Lee, Xin‐Yuan Guan
Format:	Article
Language:	English
Published:	Wolters Kluwer Health/LWW 2022-11-01
Series:	Hepatology Communications
Online Access:	https://doi.org/10.1002/hep4.1966

Similar Items

The Interactome of Cancer-Related Lysyl Oxidase and Lysyl Oxidase-Like Proteins
by: Sylvain D. Vallet, et al.
Published: (2020-12-01)

Multifunctional Lysyl Oxidases
by: Philip C. Trackman
Published: (2023-03-01)

Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis
by: Gavin Tjin, et al.
Published: (2017-11-01)

Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-β/collagen pathway in preeclampsia
by: Xiang-Hong Xu, et al.
Published: (2019-02-01)

Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer
by: Hung-Yu Lin, et al.
Published: (2020-12-01)

Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer
by: Ozge Saatci, et al.
Published: (2020-05-01)

Lysyl oxidase polymorphisms and susceptibility to osteosarcoma.
by: Yang Liu, et al.
Published: (2012-01-01)

An in situ activity assay for lysyl oxidases
by: Huilei Wang, et al.
Published: (2021-07-01)

Serum Lysyl Oxidase Levels and Lysyl Oxidase Gene Polymorphism in Ovarian Cancer Patients of Eastern Indian Population
by: Suchitra Kumari, et al.
Published: (2021-12-01)

Knock-Out of the Five Lysyl-Oxidase Family Genes Enables Identification of Lysyl-Oxidase Pro-Enzyme Regulated Genes
by: Tatyana Liburkin-Dan, et al.
Published: (2022-09-01)

Fibrosis in Mesothelioma: Potential Role of Lysyl Oxidases
by: Lara Perryman, et al.
Published: (2022-02-01)

Purification procedure and assay for the activity of lysyl oxidase
by: .O. O. Gudkova, et al.
Published: (2018-11-01)

Retraction: Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma
Published: (2022-01-01)

Retraction: Lysyl Oxidase Polymorphisms and Susceptibility to Osteosarcoma.
by: PLOS ONE Editors
Published: (2022-01-01)

Research progress of lysyl oxidase and ophthalmic diseases
by: Man Yang, et al.
Published: (2020-12-01)

Targeting lysyl oxidase reduces peritoneal fibrosis.
by: Christopher R Harlow, et al.
Published: (2017-01-01)

Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture
by: Poh, Patrina S. P., et al.
Published: (2018)

Inhibiting Lysyl Oxidases prevents pathologic cartilage calcification
by: Ilaria Bernabei, et al.
Published: (2024-02-01)

Lysyl Oxidase (LOX): Functional Contributions to Signaling Pathways
by: Rozalia Laczko, et al.
Published: (2020-07-01)

Lysyl Oxidase Family Enzymes and Their Role in Tumor Progression
by: Tanya Liburkin-Dan, et al.
Published: (2022-06-01)

Mechanistic insight into lysyl oxidase in vascular remodeling and angiogenesis
by: Zhao-Jun Wang, et al.
Published: (2023-05-01)

The Role of Lysyl Oxidase Enzymes in Cardiac Function and Remodeling
by: Cristina Rodríguez, et al.
Published: (2019-11-01)

Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation
by: Weiping Lin, et al.
Published: (2020-04-01)

The Expression Patterns and Roles of Lysyl Oxidases in Aortic Dissection
by: Xin Yi, et al.
Published: (2021-07-01)

Author Correction: An in situ activity assay for lysyl oxidases
by: Huilei Wang, et al.
Published: (2021-09-01)

Effect of Anti-Hypertensive Medication on Plasma Concentrations of Lysyl Oxidase: Evidence for Aldosterone-IL-6-Dependent Regulation of Lysyl Oxidase Blood Concentration
by: Rolf Schreckenberg, et al.
Published: (2022-07-01)

Collagen cross-links scale with passive stiffness in dystrophic mouse muscles, but are not altered with administration of a lysyl oxidase inhibitor.
by: Sarah E Brashear, et al.
Published: (2022-01-01)

Correction: Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis (doi: 10.1242/dmm.030114)
by: Gavin Tjin, et al.
Published: (2017-12-01)

Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer
by: Wei Wang, et al.
Published: (2022-10-01)

Oligomeric States and Hydrodynamic Properties of Lysyl Oxidase-Like 2
by: Alex A. Meier, et al.
Published: (2021-12-01)

Lysyl Oxidases: Orchestrators of Cellular Behavior and ECM Remodeling and Homeostasis
by: Shelly Zaffryar-Eilot, et al.
Published: (2022-09-01)

Corrigendum: Molecular Insights Into Lysyl Oxidases in Cartilage Regeneration and Rejuvenation
by: Weiping Lin, et al.
Published: (2020-10-01)

A 3D–Predicted Structure of the Amine Oxidase Domain of Lysyl Oxidase–Like 2
by: Alex A. Meier, et al.
Published: (2022-11-01)

Properties of a cryptic lysyl oxidase from haloarchaeon Haloterrigena turkmenica
by: Nikolay B. Pestov, et al.
Published: (2019-04-01)

Mass Spectrometry-Based Disulfide Mapping of Lysyl Oxidase-like 2
by: Alex A. Meier, et al.
Published: (2022-05-01)

Association of 2 Lysyl Oxidase Gene Single Nucleotide Polymorphisms with Keratoconus
by: Sana Niazi, MD, et al.
Published: (2023-06-01)

2027 The role of lysyl oxidase in systemic sclerosis-associated lung fibrosis
by: Xinh-Xinh Nguyen, et al.
Published: (2018-06-01)

Lysyl Oxidases Expression and Breast Cancer Progression: A Bioinformatic Analysis
by: Sofia Ramos, et al.
Published: (2022-06-01)

Tendon mechanical properties are enhanced via recombinant lysyl oxidase treatment
by: Phong K. Nguyen, et al.
Published: (2022-08-01)

Lysyl oxidase inhibitors attenuate cyclosporin A-induced nephropathy in mouse
by: Long T. Nguyen, et al.
Published: (2021-06-01)