CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells.

CXCR4 mediated chemotaxis is regulated by 5T4 oncofetal glycoprotein in mouse embryonic cells.

5T4 oncofetal molecules are highly expressed during development and upregulated in cancer while showing only low levels in some adult tissues. Upregulation of 5T4 expression is a marker of loss of pluripotency in the early differentiation of embryonic stem (ES) cells and forms an integrated componen...

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Bibliographic Details
Main Authors: Thomas D Southgate, Owen J McGinn, Fernanda V Castro, Andrzej J Rutkowski, Mariam Al-Muftah, Georgi Marinov, Graeme J Smethurst, David Shaw, Christopher M Ward, Crispin J Miller, Peter L Stern
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2848608?pdf=render

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http://europepmc.org/articles/PMC2848608?pdf=render

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