Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche

Decoding of the surfaceome and endocytome in primary glioblastoma cells identifies potential target antigens in the hypoxic tumor niche

Abstract Immunotherapies with antibody–drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenviron...

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Bibliographic Details
Main Authors: Kelin Gonçalves de Oliveira, Anna Bång-Rudenstam, Sarah Beyer, Axel Boukredine, Hugo Talbot, Valeria Governa, Maria C. Johansson, Ann-Sofie Månsson, Karin Forsberg-Nilsson, Johan Bengzon, Johan Malmström, Charlotte Welinder, Mattias Belting
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Acta Neuropathologica Communications
Subjects:
Immunotherapy
Glioblastoma
Tumor antigens
Proteomics
Hypoxia
Online Access:https://doi.org/10.1186/s40478-024-01740-z

Internet

https://doi.org/10.1186/s40478-024-01740-z

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