High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene

High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene

Objective: Association between prostate cancer and obesity remains controversial. Allelic deletions of PTEN, a tumor suppressor gene, are common in prostate cancer in men. Monoallelic Pten deletion in mice causes low prostatic intraepithelial neoplasia (mPIN). This study tested the effect of a hyper...

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Bibliographic Details
Main Authors: Jehnan Liu, Sadeesh K. Ramakrishnan, Saja S. Khuder, Meenakshi K. Kaw, Harrison T. Muturi, Sumona Ghosh Lester, Sang Jun Lee, Larisa V. Fedorova, Andrea J. Kim, Iman E. Mohamed, Cara Gatto-Weis, Kathryn M. Eisenmann, Philip B. Conran, Sonia M. Najjar
Format: Article
Language:English
Published: Elsevier 2015-03-01
Series:Molecular Metabolism
Subjects:
PTEN tumor suppression
Hyperinsulinemia
Fatty acid synthase
Neoplasia
Prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877814002245

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http://www.sciencedirect.com/science/article/pii/S2212877814002245

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