Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina

Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina

Purpose: To investigate the effect of a selective aquaporin 4 (AQP4) inhibitor, 2-(nicotinamide)-1,3,4-thiadiazole (TGN-020), on the expression of vascular endothelial growth factor (VEGF) and reactive oxygen species (ROS) production, as well as on the retinal edema in diabetic retina. Methods: Intr...

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Bibliographic Details
Main Authors: Shou Oosuka, Teruyo Kida, Hidehiro Oku, Taeko Horie, Seita Morishita, Masanori Fukumoto, Takaki Sato, Tsunehiko Ikeda
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
aquaporin 4 (AQP4)
TGN-020
reactive oxygen species (ROS)
vascular endothelial growth factor (VEGF)
Müller cell
diabetic macular edema
Online Access:https://www.mdpi.com/1422-0067/21/7/2324

Internet

https://www.mdpi.com/1422-0067/21/7/2324

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