Neuroprotective Effect of Dexmedetomidine against Postoperative Cognitive Decline via NLRP3 Inflammasome Signaling Pathway

Neuroprotective Effect of Dexmedetomidine against Postoperative Cognitive Decline via NLRP3 Inflammasome Signaling Pathway

Dexmedetomidine (Dex), widely used as a sedative in surgical procedures and intensive care units, induces sympatholytic, anxiolytic, analgesic, and sedative effects. Postoperative cognitive dysfunction (POCD) is routinely observed in postoperative care following surgery and general anesthesia. The N...

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Bibliographic Details
Main Authors: Inja Cho, Bon-Nyeo Koo, So Yeon Kim, Sujung Park, Eun Jung Kim, Eun Hee Kam, Jeongmin Kim
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
antioxidant
dexmedetomidine
inflammation
NLRP3 inflammasome
reactive oxygen species
postoperative cognitive dysfunction
Online Access:https://www.mdpi.com/1422-0067/23/15/8806

Internet

https://www.mdpi.com/1422-0067/23/15/8806

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