APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

APPsα rescues CDK5 and GSK3β dysregulation and restores normal spine density in Tau transgenic mice

The Tau protein can be phosphorylated by numerous kinases. In Alzheimer’s disease (AD) hyperphosphorylated Tau species accumulate as neurofibrillary tangles that constitute a major hallmark of AD. AD is further characterized by extracellular Aβ plaques, derived from the β-amyloid precursor protein A...

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Bibliographic Details
Main Authors: Danny Baltissen, Charlotte S. Bold, Lena Rehra, Marija Banićević, Justus Fricke, Jennifer Just, Susann Ludewig, Christian J. Buchholz, Martin Korte, Ulrike C. Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
Tau
CDK5
GSK3β
APPsα
THY-Tau22
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1106176/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1106176/full

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