Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes

Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapes

Abstract Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially targets single-stranded DNAs, with a noted affinity for DNA regions that adopt stem-loop secondary structures. However, the...

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Bibliographic Details
Main Authors: Ambrocio Sanchez, Pedro Ortega, Ramin Sakhtemani, Lavanya Manjunath, Sunwoo Oh, Elodie Bournique, Alexandrea Becker, Kyumin Kim, Cameron Durfee, Nuri Alpay Temiz, Xiaojiang S. Chen, Reuben S. Harris, Michael S. Lawrence, Rémi Buisson
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45909-5

Internet

https://doi.org/10.1038/s41467-024-45909-5

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