Autophagy Protects against Eosinophil Cytolysis and Release of DNA

Autophagy Protects against Eosinophil Cytolysis and Release of DNA

The presence of eosinophils in the airway is associated with asthma severity and risk of exacerbations. Eosinophils deposit their damaging products in airway tissue, likely by degranulation and cytolysis. We previously showed that priming blood eosinophils with IL3 strongly increased their cytolysis...

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Bibliographic Details
Main Authors: Stephane Esnault, Paul S. Fichtinger, Karina T. Barretto, Frances J. Fogerty, Ksenija Bernau, Deane F. Mosher, Sameer K. Mathur, Nathan Sandbo, Nizar N. Jarjour
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
eosinophils
autophagy
cytolysis
DNA traps
SQSTM1
MAP1LC3B
Online Access:https://www.mdpi.com/2073-4409/11/11/1821

Internet

https://www.mdpi.com/2073-4409/11/11/1821

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