Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

Evaluation of commonly used analysis strategies for epigenome- and transcriptome-wide association studies through replication of large-scale population studies

Abstract Background A large number of analysis strategies are available for DNA methylation (DNAm) array and RNA-seq datasets, but it is unclear which strategies are best to use. We compare commonly used strategies and report how they influence results in large cohort studies. Results We tested the...

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Bibliographic Details
Main Authors: Jeroen van Rooij, Pooja R. Mandaviya, Annique Claringbould, Janine F. Felix, Jenny van Dongen, Rick Jansen, Lude Franke, BIOS consortium, Peter A. C. ’t Hoen, Bas Heijmans, Joyce B. J. van Meurs
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Genome Biology
Subjects:
Illumina 450k arrays
DNA methylation
EWAS
RNA sequencing
Differential gene expression
TWAS
Online Access:http://link.springer.com/article/10.1186/s13059-019-1878-x

Internet

http://link.springer.com/article/10.1186/s13059-019-1878-x

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