Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis

Distinct COPD subtypes in former smokers revealed by gene network perturbation analysis

Abstract Background Chronic obstructive pulmonary disease (COPD) varies significantly in symptomatic and physiologic presentation. Identifying disease subtypes from molecular data, collected from easily accessible blood samples, can help stratify patients and guide disease management and treatment....

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Bibliographic Details
Main Authors: Kristina L. Buschur, Craig Riley, Aabida Saferali, Peter Castaldi, Grace Zhang, Francois Aguet, Kristin G. Ardlie, Peter Durda, W. Craig Johnson, Silva Kasela, Yongmei Liu, Ani Manichaikul, Stephen S. Rich, Jerome I. Rotter, Josh Smith, Kent D. Taylor, Russell P. Tracy, Tuuli Lappalainen, R. Graham Barr, Frank Sciurba, Craig P. Hersh, Panayiotis V. Benos
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Respiratory Research
Subjects:
COPD
Graphical models
Gene expression
Disease subtypes
Online Access:https://doi.org/10.1186/s12931-023-02316-6

Internet

https://doi.org/10.1186/s12931-023-02316-6

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