Pannexin-1 Deficient Mice Have an Increased Susceptibility for Atrial Fibrillation and Show a QT-Prolongation Phenotype

Pannexin-1 Deficient Mice Have an Increased Susceptibility for Atrial Fibrillation and Show a QT-Prolongation Phenotype

Background/Aims: Pannexin-1 (Panx1) is an ATP release channel that is ubiquitously expressed and coupled to several ligand-gated receptors. In isolated cardiac myocytes, Panx1 forms large conductance channels that can be activated by Ca2+ release from the sarcoplasmic reticulum. Here we characterize...

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Bibliographic Details
Main Authors: Stella Petric, Sofia Klein, Lisa Dannenberg, Tillman Lahres, Lukas Clasen, Klaus G. Schmidt, Zhaoping Ding, Birgit C. Donner
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cardiac ion channels
Pannexin-1
Knock-out
In vivo electrophysiology
Cardiac repolarization
QT prolongation
Atrial fibrillation
Online Access:http://www.karger.com/Article/FullText/438645

Internet

http://www.karger.com/Article/FullText/438645

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