Composites of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide with Polymers: Effect of Crystallinity on Solubility and Stability

Composites of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide with Polymers: Effect of Crystallinity on Solubility and Stability

This work aimed to develop and characterize a water-soluble, high-release active pharmaceutical ingredient (API) composite based on the practically water-insoluble API N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-3), a substance with antidepressant and anxiolytic action. This a...

Full description

Bibliographic Details
Main Authors: Vladimir B. Markeev, Evgenia V. Blynskaya, Sergey V. Tishkov, Konstantin V. Alekseev, Anna I. Marakhova, Alexandre A. Vetcher, Alexander Y. Shishonin
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
amorphous solid dispersions
composite
solubility
bioavailability
anxiolytics
antidepressants
Online Access:https://www.mdpi.com/1422-0067/24/15/12215

Internet

https://www.mdpi.com/1422-0067/24/15/12215

Similar Items